Are duplex kidneys hereditary?

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mummysdiary.co.ukImage: mummysdiary.co.ukDuplex kidney is a result of errors in cell division that occur during the development of the fetus inside the mother’s womb. There is no evidence that suggests anything during pregnancy causes the defect. However, there is evidence to show that the condition can be passed from parent to child.

Are duplex kidney phenotypes associated with genetic factors?

Indeed, our own unpublished data suggest that duplex kidney phenotypes can be highly genetic background–dependent, indicating the presence of modifier genes. Moreover, intergenic/regulatory mutations or epigenetic mechanisms that affect gene expression levels rather than protein function are likely to contribute to disease.

What causes a duplex kidney?

A duplex kidney can occur with other abnormalities of your urinary system. One common abnormality is an ureterocele, which occurs when the end of the ureter does not develop properly, and urine flow is obstructed. This results in a balloon-like swelling as urine builds up at the point where the ureter and bladder connect.

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How common are duplex kidneys in children?

Duplex kidneys are a normal variant, meaning that they occur commonly enough in healthy children to be considered normal. They occur in 1 percent of the population, and most cause no medical problems and will require no treatment. Other duplex kidneys can be associated with the following: Vesicoureteral reflux (VUR)

What is the prognosis of duplex kidney disease?

Postoperatively patients tend to recover well, though some patients may experience a decline in renal function in the remaining renal moiety or recurrent urinary tract infections which may necessitate further surgery.10 Conclusion Duplex kidneys are usually clinically silent, however, when significant will tend to present in children.


Duplex Kidneys… animated patient info


More about Are duplex kidneys hereditary?


1. Duplex Kidney (Duplicated Ureters): Diagnosis, Cause & Symptoms

There is no evidence that suggests anything during pregnancy causes the defect. However, there is evidence to show that the condition can be passed from parent to child. If one parent has a duplex kidney, the child has a 50-50 chance of also being born with this condition.

From my.clevelandclinic.org

2. Duplex kidney formation: developmental mechanisms and genetic …

Jan 06, 2020 · Indeed, our own unpublished data suggest that duplex kidney phenotypes can be highly genetic background–dependent, indicating the presence of modifier genes. Moreover, intergenic/regulatory mutations or epigenetic mechanisms that affect gene expression levels rather than protein function are likely to contribute to disease.

From www.ncbi.nlm.nih.gov

4. Duplex Kidney – Children’s Hospital of Philadelphia

In a normal urinary tract, each kidney is connected to one ureter (a tube that drains urine into the bladder). Children with a duplex kidney (also called a duplicated collecting system) have two ureters coming from a single kidney. These two ureters can drain independently into the bladder or connect and drain as a single ureter into the bladder.

From www.chop.edu

5. Duplex kidney formation: developmental mechanisms and genetic …

Congenital abnormalities of the kidney and urinary tract (CAKUT) are a highly diverse group of diseases that together belong to the most common abnormalities detected in the new-born child. Consistent with this diversity, CAKUT are caused by mutations in a large number of genes and present a wide spectrum of phenotypes. In this review, we will focus on duplex kidneys, a …

From pubmed.ncbi.nlm.nih.gov

6. Adult duplex kidneys: an important differential diagnosis in patients …

Feb 12, 2013 · Duplex collecting systems are one of the most common congenital anomalies, with an incidence of 0.8%. 1 It is bilateral in 20% of these and is more common in women than in men.

From www.ncbi.nlm.nih.gov

7. 5. Hereditary Kidney Disorders – PMC – PubMed Central (PMC)

Apr 20, 2009 · Hereditary kidney disorders represent significant risk for the development of end stage renal desease (ESRD). Most of them are recognized in childhood, or prenataly particularly those phenotypicaly expressed as anomalies on ultrasound examination (US) during pregnancy. They represent almost 50% of all fetal malformations detected by US . Furthermore many of …

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From www.ncbi.nlm.nih.gov

8. duplex kidney – General Practice Notebook

Duplex kidney is the most common congenital abnormality of the urinary tract with a reported urographic incidence of around 2% (1) presentation is either as an incidental finding or as a cause of recurrent infection. Other presentations include obstruction, stasis and stone.

From gpnotebook.com

9. Duplex kidney | Great Ormond Street Hospital – GOSH Hospital site

We need to take extra precautions to keep patients, families and staff as safe as we can. That’s why it’s really important to follow the latest GOSH COVID-19 guidance. To help keep everyone at GOSH safe, please: ― Wear a fluid resistant surgical mask – the hospital will provide these. ― Practice good social distancing and hand hygiene.

From www.gosh.nhs.uk


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