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The mechanism of action of busulfan is as an Alkylating Activity. L01AB01 L – Antineoplastic and immunomodulating agents L01 – Antineoplastic agents L01A – Alkylating agents L01AB – Alkyl sulfonates L01AB01 – Busulfan Completely absorbed from the gastrointestinal tract.
What is the mechanism of action of busulfan?
Busulfan is a mutagen and a clastogen. In in vitro tests it caused mutations in Salmonella typhimurium and Drosophila melanogaster. Chromosomal aberrations induced by busulfan have been reported in vivo (rats, mice, hamsters, and humans) and in vitro (rodent and human cells).
Is busulfan a mutagen?
The metabolism of Busulfan can be increased when combined with Medroxyprogesterone acetate. The risk or severity of adverse effects can be increased when Busulfan is combined with Melphalan. The metabolism of Busulfan can be decreased when combined with Meperidine.
Busulfan USMLE Mnemonic Preview
More about What does busulfan react with?
1. Busulfan Side Effects: Common, Severe, Long Term – Drugs.com
Oct 05, 2021 · fast, pounding, or irregular heartbeat or pulse fever or chills headache lower back or side pain nervousness pain and fullness in the upper abdominal or stomach painful or difficult urination pinpoint red spots on the skin pounding in the ears skin rash or itching slow heartbeat swelling of the eyes or eyelids tightness in the chest
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2. Busulfan – Wikipedia
Busulfan is an alkylsulfonate. It is an alkylating agent that forms DNA-DNA interstrand crosslinks between the DNA bases guanine and adenine and between guanine and guanine. This occurs through an SN2 reaction in which the relatively nucleophilic guanine N7 attacks the carbon adjacent to the mesylate leaving group. DNA crosslinking prevents DNA replication. Because the intrastrand DNA crosslinks cannot be repaired by cellular machinery, the cell undergoes apoptosis.
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3. Busulfan | C6H14O6S2 – PubChem
The primary molecular action of busulfan is alkylation of intracellular nucleophiles. Both proteins and nucleic acids are affected. With regard to DNA, busulfan reacts with guanine residues to form a fourcarbon di-guanine DNA cross-linkage with release of methylsulfonate. The DNA cross-linkage causes misreading of the DNA code and single-strand breakage.
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4. Busulfan Tablet: Indications, Side Effects, Warnings – Drugs.com
Aug 24, 2021 · Very bad and sometimes deadly liver problems have happened with busulfan tablet. Call your doctor right away if you have signs of liver problems like dark urine, feeling tired, not hungry, upset stomach or stomach pain, light-colored stools, throwing up, …
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5. Busulfan: Uses, Interactions, Mechanism of Action – DrugBank
427 rows · Busulfan is predominantly metabolized by conjugation with glutathione, both …
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6. Busulfan (Intravenous Route) Side Effects – Mayo Clinic
Feb 01, 2022 · Busulfan belongs to the group of medicines known as alkylating agents. It seems to act by interfering with the function of the bone marrow. Since the growth of normal body cells may also be affected by busulfan, other effects will also occur. Some of these may be serious and must be reported to your doctor.
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7. Busulfan – Drug Information – Chemocare
Myleran is another name for busulfan. In some cases, health care professionals may use the trade name bulsufex or other names myleran when referring to the generic drug name busulfan. Drug type: Busulfan is an anti-cancer (“antineoplastic” or “cytotoxic”) chemotherapy drug. This medication is classified as an “alkylating agent.”
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8. Busulfex (Busulfan): Uses, Dosage, Side Effects, Interactions … – RxList
Mar 17, 2021 · Busulfan is a bifunctional alkylating agent in which two labile methanesulfonate groups are attached to opposite ends of a four-carbon alkyl chain. In aqueous media, busulfan hydrolyzes to release the methanesulfonate groups. This produces reactive carbonium ions that can alkylate DNA.
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9. Busulfan: MedlinePlus Drug Information
Busulfan may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away: nausea diarrhea loss of appetite or weight constipation sores in the mouth and throat dry mouth headache difficulty falling asleep or staying asleep feeling unusually anxious or worried dizziness
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10. Busulfan – NCI – National Cancer Institute
Feb 21, 2014 · Busulfan is approved to treat: Chronic myelogenous leukemia (CML). It is used as palliative treatment. This use is approved for the Myleran brand of busulfan. It is also used with other drugs to prepare patients with CML for a stem cell transplant. This use is approved for the Busulfex brand of busulfan. Busulfan is also being studied in the …
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